Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 12, 2026

The Attentional Set Shifting Task: A Measure of Cognitive Flexibility in Mice
09:15

The Attentional Set Shifting Task: A Measure of Cognitive Flexibility in Mice

Published on: February 4, 2015

The mouse attentional-set-shifting task: a method for assaying successful cognitive aging?

Jared W Young1, Susan B Powell, Mark A Geyer

  • 1University of California, San Diego, La Jolla, California 92093-0804, USA.

Cognitive, Affective & Behavioral Neuroscience
|May 26, 2010
PubMed
Summary

Aged mice show greater variability in executive function, similar to humans. This research introduces a new model for studying cognitive aging and individual differences in frontal cortex function.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Psychological Factors, Physical Conditions, and Functioning Among US Veterans.

JAMA network open·2024
Same author

A New Paradigm for High-dimensional Data: Distance-Based Semiparametric Feature Aggregation Framework via Between-Subject Attributes.

Scandinavian journal of statistics, theory and applications·2024
Same author

Aspects of Area Deprivation Index in Relation to Hippocampal Volume Among Children.

JAMA network open·2024
Same author

Well-being domains in U.S. military veterans: identifying modifiable factors to promote whole health.

International psychogeriatrics·2024
Same author

Cognition and Functional Capacity: An Initial Comparison of Veteran and Non-Veteran Older Adults.

Military medicine·2024
Same author

The influence of economic policies on social environments and mental health.

Bulletin of the World Health Organization·2024

Area of Science:

  • Neuroscience
  • Cognitive Aging
  • Animal Models

Background:

  • Human cognitive decline with age varies significantly.
  • Rodent models exist for hippocampal aging but not frontal cortex decline.
  • Understanding individual differences in cognitive aging is crucial.

Purpose of the Study:

  • To test if aged mice show greater variance in executive function compared to young mice.
  • To establish a rodent model for studying age-related executive function decline.
  • To identify mechanisms underlying successful cognitive aging.

Main Methods:

  • Young and aged C57BL/6N mice were tested using the attentional-set-shifting task.
  • Performance was measured by trials-to-criterion and latency during extradimensional shifting.

More Related Videos

An Operant Intra-/Extra-dimensional Set-shift Task for Mice
08:35

An Operant Intra-/Extra-dimensional Set-shift Task for Mice

Published on: January 22, 2016

Operant Procedures for Assessing Behavioral Flexibility in Rats
08:30

Operant Procedures for Assessing Behavioral Flexibility in Rats

Published on: February 15, 2015

Related Experiment Videos

Last Updated: Jun 12, 2026

The Attentional Set Shifting Task: A Measure of Cognitive Flexibility in Mice
09:15

The Attentional Set Shifting Task: A Measure of Cognitive Flexibility in Mice

Published on: February 4, 2015

An Operant Intra-/Extra-dimensional Set-shift Task for Mice
08:35

An Operant Intra-/Extra-dimensional Set-shift Task for Mice

Published on: January 22, 2016

Operant Procedures for Assessing Behavioral Flexibility in Rats
08:30

Operant Procedures for Assessing Behavioral Flexibility in Rats

Published on: February 15, 2015

  • Variance in performance between young and aged groups was compared.

    • Main Results:

    • No significant difference in trials-to-criterion performance between young and aged mice.
    • Aged mice exhibited significantly greater variance in latency during extradimensional shifting.
    • This indicates increased individual differences in executive function in aged mice.

    Conclusions:

    • The attentional-set-shifting task can model age-related executive function variability in mice.
    • This model may help identify mechanisms behind successful frontal-cortex-mediated cognitive aging.
    • Individual differences in cognitive decline are a key area for future research.