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Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...

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Updated: Jun 12, 2026

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples

Published on: October 2, 2020

Targeting breast cancer stem cells.

Suling Liu¹, Max S Wicha

¹Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology

|May 26, 2010

Summary

Breast cancer stem cells (BCSCs) resist treatment and cause relapse. Targeting BCSCs offers a promising strategy to improve outcomes for breast cancer patients.

Area of Science:

Oncology
Cancer Stem Cell Biology

Background:

Increasing evidence suggests cancer, including breast cancer, harbors stem-cell-like populations.
These breast cancer stem cells (BCSCs) exhibit resistance to conventional therapies like radiation and chemotherapy.
BCSCs are implicated in treatment resistance and disease relapse.

Purpose of the Study:

To explore the role of BCSCs in breast cancer treatment resistance.
To identify and evaluate therapeutic targets regulating BCSCs.
To assess the potential of novel agents targeting BCSCs in clinical settings.

Main Methods:

Review of preclinical models and emerging clinical trial data.
Elucidation of molecular pathways regulating BCSCs.
Development of innovative clinical trial designs with specific endpoints.

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Last Updated: Jun 12, 2026

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples

Published on: October 2, 2020

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

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Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

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Main Results:

Identification of key pathways regulating BCSCs.
Preclinical agents targeting BCSCs show promise.
Novel therapeutic agents are entering clinical trials.

Conclusions:

Targeting BCSCs is a critical strategy for overcoming treatment resistance in breast cancer.
Effective targeting of BCSCs could significantly improve patient outcomes in early-stage and advanced breast cancer.
Innovative clinical trial designs are essential for evaluating BCSCs-targeting agents.