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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Related Experiment Video

Updated: Jun 12, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Diffuse low-grade oligodendrogliomas extend beyond MRI-defined abnormalities.

J Pallud1, P Varlet, B Devaux

  • 1Service de Neurochirurgie, Hôpital Sainte-Anne, Paris cedex 14, France. johanpallud@hotmail.com

Neurology
|May 26, 2010
PubMed
Summary
This summary is machine-generated.

Conventional MRI underestimates the full size of diffuse low-grade gliomas (DLGGs). This suggests extending surgical resection beyond MRI-defined areas may improve patient outcomes for these brain tumors.

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Area of Science:

  • Neuro-oncology
  • Medical imaging
  • Neurosurgery

Background:

  • Accurate delineation of diffuse low-grade gliomas (DLGGs) is crucial for surgical planning.
  • Conventional MRI's ability to define the precise spatial extent of DLGGs remains unclear.

Purpose of the Study:

  • To investigate the accuracy of preoperative conventional MRI in delineating DLGGs.
  • To correlate MRI findings with histologic analysis of tumor extent.

Main Methods:

  • Retrospective study of 16 adult patients with untreated supratentorial DLGGs.
  • Stereotactic biopsies performed within and beyond MRI-defined abnormalities.
  • Histologic analysis of biopsy samples, including MIB-1 immunostaining.

Main Results:

  • Thirty-seven biopsy samples taken beyond MRI-defined areas showed MIB-1-positive cells, indicating tumor presence.
  • MIB-1-positive cells were identified as cycling tumor cells, distinct from glial fibrillary acidic protein expression.
  • Tumor cell presence beyond MRI margins decreased with distance from the visible tumor.

Conclusions:

  • Conventional MRI underestimates the true spatial extent of DLGGs.
  • Surgical resection margins should extend beyond MRI-defined abnormalities in non-eloquent brain areas to potentially improve outcomes.