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Updated: Jun 12, 2026

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
Published on: June 12, 2021
Molecular sonography with targeted microbubbles: current investigations and potential applications
Misun Hwang1, Andrej Lyshchik, Arthur C Fleischer
1Vanderbilt University School of Medicine and Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN 37232-2675, USA. arthur.fleischer@vanderbilt.edu
Targeted microbubble sonography offers advanced cellular and molecular imaging for early disease diagnosis and personalized therapy. Its advantages make it a promising tool for future clinical trials.
Area of Science:
- Medical Imaging
- Biotechnology
- Molecular Diagnostics
Background:
- Sonography with targeted microbubbles provides novel functional information at cellular and molecular levels.
- This advanced imaging technique enables early disease detection and the development of molecular-level therapeutic strategies.
Purpose of the Study:
- To review the fundamental concepts of targeted microbubble-enhanced sonography.
- To explore its diverse potential clinical applications in diagnostics and therapeutics.
Main Methods:
- Review of scientific literature on targeted microbubble-enhanced sonography.
- Analysis of current and potential clinical uses.
Main Results:
- Targeted microbubble sonography yields functional insights for early disease diagnosis and personalized treatment planning.
- It aids in monitoring tumor response to therapy by assessing the molecular state.
Conclusions:
- Targeted microbubble-enhanced sonography presents significant advantages, including cost-effectiveness, speed, and lack of radiation.
- Its unique capabilities position it as a key imaging modality for future clinical trials focused on molecular imaging's impact on treatment outcomes.
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