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Serum ferritin spectrotypes in patients with heterozygous beta-thalassaemia
Y Lasne1, A Francina, O Benzerara
1Laboratoire Central des Isotopes, Hôpital Edouard Herriot, Lyon, France.
Abstract:
Serum ferritin spectrotypes from patients heterozygous for beta-thalassaemia were determined after agarose isoelectric focusing followed by radio-immunofixation with anti-ferritin antibody. Multivariate analysis demonstrated a specific spectrotype for heterozygous beta-thalassaemia. This spectrotype was shown to be different from those in hereditary spherocytosis and idiopathic haemochromatosis. Statistical discrimination reached 100% of well-classified patients between these pathological conditions.

