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Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

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Related Experiment Video

Updated: Jun 12, 2026

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
08:02

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction

Published on: January 22, 2020

Human FOXP3 and cancer.

F Martin1, S Ladoire, G Mignot

  • 1Equipe Avenir, INSERM UMR 866, University of Burgundy, Dijon, France.

Oncogene
|May 26, 2010
PubMed
Summary
This summary is machine-generated.

Forkhead box protein 3 (FOXP3) is crucial for regulatory T cell immunosuppression and can be expressed in other cells, impacting oncogenes. Its roles in T cells and tumor cells offer prognostic significance in malignancies.

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In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol
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In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol

Published on: December 30, 2016

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Last Updated: Jun 12, 2026

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
08:02

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In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol
08:20

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol

Published on: December 30, 2016

Area of Science:

  • Immunology
  • Molecular Biology
  • Oncology

Background:

  • Forkhead box protein 3 (FOXP3) is a key transcription factor for regulatory T cell immunosuppressive functions.
  • While initially considered T cell-specific, FOXP3 expression is also observed in nonregulatory T cells and non-lymphoid cells.
  • FOXP3's role in repressing oncogenes in non-lymphoid cells, with restoration upon deletion/mutation, highlights its broader significance.

Purpose of the Study:

  • To review advances in understanding FOXP3 functions in human regulatory T cells.
  • To examine the prognostic significance of FOXP3-expressing T cells in human malignancies.
  • To elucidate the importance of FOXP3 expression within human tumor cells.

Main Methods:

  • Literature review of recent studies on FOXP3.
  • Analysis of FOXP3 expression patterns in various human cell types.
  • Synthesis of data regarding FOXP3's functional roles and prognostic implications.

Main Results:

  • FOXP3 is essential for regulatory T cell function but also expressed transiently in activated nonregulatory T cells.
  • FOXP3 expression in non-lymphoid cells suggests a role in tumor suppression by repressing oncogenes.
  • FOXP3-expressing T cells and tumor cells have prognostic relevance in human cancers.

Conclusions:

  • FOXP3 has diverse roles beyond regulatory T cells, including potential tumor suppressor activity.
  • FOXP3 expression serves as a valuable prognostic marker in various human malignancies.
  • Further research into FOXP3's multifaceted roles can inform cancer therapies.