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Is the rapid sequence induction possible with 0.6 mg/kg rocuronium in pediatric patient?

Sang Kyu Lee1, Ji Hee Hong, Ae Ra Kim

  • 1Department of Anesthesiology and Pain Medicine, Keimyung University College of Medicine, Daegu, Korea.

Korean Journal of Anesthesiology
|May 26, 2010
PubMed

Insights

This study explored rocuronium for rapid sequence induction (RSI) in children. The timing of rocuronium administration did not significantly impact clinically acceptable intubation conditions.

Area of Science:

  • Anesthesiology
  • Pediatric Anesthesia
  • Pharmacology

Background:

  • Investigated rocuronium 0.6 mg/kg for rapid sequence induction (RSI) in pediatric patients.
  • Focused on children aged 4-8 years undergoing elective surgery.

Purpose of the Study:

  • To evaluate the efficacy of the timing principle in conjunction with rocuronium for pediatric RSI.
  • To compare intubating conditions based on the sequence of rocuronium and propofol administration.

Main Methods:

  • Randomized study of 65 children (aged 4-8 years) into two groups.
  • Group A: Rocuronium (0.6 mg/kg) followed by propofol (2.5 mg/kg).
  • Group B: Propofol followed by rocuronium (0.6 mg/kg); intubation assessed at 60 seconds.

Main Results:

  • Excellent intubation conditions achieved in 87% (Group A) vs. 61% (Group B).
  • Clinically acceptable intubation conditions (excellent and good) were comparable: 100% (Group A) vs. 99% (Group B).
  • No significant difference in clinically acceptable intubation outcomes between the groups.

Conclusions:

  • Rapid sequence induction (RSI) with rocuronium is feasible in pediatric patients regardless of the timing principle.
  • The sequence of rocuronium and propofol administration does not critically affect successful intubation in this pediatric population.
  • Rocuronium at 0.6 mg/kg provides effective intubating conditions for pediatric RSI.
Abstract

Keywords:
Intubation conditionRapid sequence inductionRocuroniumTiming principle

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