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Fabricating Highly Open Porous Microspheres (HOPMs) via Microfluidic Technology

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Published on: May 16, 2022

Development and optimization of micro/nanoporous osmotic pump tablets.

Siracha Tuntikulwattana¹, Ampol Mitrevej, Teerakiat Kerdcharoen

¹Department of Industrial Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, 10400, Thailand.

AAPS Pharmscitech

|May 26, 2010

Summary

This study developed micro/nanoporous osmotic pump tablets using polyvinylpyrolidone (PVP) for controlled drug release. Optimized formulations achieved predictable 12- and 24-hour propranolol hydrochloride release profiles.

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Area of Science:

Pharmaceutical Technology
Materials Science

Background:

Osmotic pump tablets offer controlled drug delivery.
Developing micro/nanoporous membranes is key for precise release kinetics.

Purpose of the Study:

To optimize micro/nanoporous osmotic pump tablets for controlled drug release.
To evaluate the impact of pore former type and coating level on drug release profiles.

Main Methods:

Fabrication of cellulose acetate-coated tablets with polyvinylpyrolidone (PVP) as pore formers.
Central composite design for formulation optimization based on USP 31 standards.
Analysis of drug release using scanning electron microscopy (SEM) and atomic force microscopy (AFM).

Main Results:

PVP effectively formed micro/nanopores in the tablet membranes.
Drug release correlated with PVP molecular weight (K30 vs. K90), concentration, and coating level.
Specific PVP K30 formulations achieved 12-hour release, while both K30 and K90 formulations yielded satisfactory 24-hour release.

Conclusions:

Formulation parameters significantly influence drug release from osmotic pump tablets.
Achieving desired release profiles (12-h vs. 24-h) depends on specific pore former characteristics and membrane thickness.
Optimized formulations demonstrated good predictability between theoretical and observed drug release.