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Urinary excretion of cyclic AMP in hyperparathyroidism
Scandinavian Journal of Urology and Nephrology
|January 1, 1978
Summary
Urinary adenosine 3', 5'-monophosphate (cAMP) levels were higher in primary hyperparathyroidism patients before surgery. Post-surgery, cAMP levels normalized, suggesting cAMP analysis aids in diagnosing this condition.
Area of Science:
- Endocrinology
- Urology
- Biochemistry
Background:
- Primary hyperparathyroidism is a condition characterized by excessive parathyroid hormone production.
- Assessing urinary biomarkers can aid in the diagnosis and management of endocrine disorders.
Purpose of the Study:
- To investigate urinary adenosine 3", 5"-monophosphate (cAMP) excretion in patients with primary hyperparathyroidism.
- To evaluate the diagnostic utility of urinary cAMP compared to parathyroid hormone (PTH) levels.
Main Methods:
- Measurement of urinary cAMP in 15 primary hyperparathyroidism patients pre- and post-parathyroidectomy.
- Comparison of cAMP excretion with urinary calcium levels and radioimmunoassay of PTH.
- Analysis of cAMP excretion per gram of creatinine in normal subjects.
Main Results:
- Elevated urinary cAMP was observed in 8 out of 15 pre-operative patients.
- Urinary cAMP levels normalized after parathyroidectomy.
- Relating cAMP to urinary calcium enhanced diagnostic discrimination.
- Urinary cAMP measurement proved superior to PTH radioimmunoassay for identifying hyperparathyroidism.
Conclusions:
- Urinary cAMP excretion is a valuable indicator in primary hyperparathyroidism.
- Post-operative normalization of cAMP supports its role as a biomarker.
- Urinary cAMP analysis offers a superior diagnostic method compared to PTH assays for this condition.