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Updated: Jun 12, 2026
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Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model
Published on: September 8, 2023
Association between bone turnover rate and bone microarchitecture in men: the STRAMBO study
Ali Chaitou1, Stephanie Boutroy, Nicolas Vilayphiou
1INSERM Research Unit 831, University of Claude Bernard Lyon 1, Lyon, France.
Summary
Bone turnover markers in men show distinct age-related patterns. After age 70, higher bone turnover significantly impacts bone microarchitecture, particularly cortical and trabecular bone.
Area of Science:
- Bone biology
- Gerontology
- Orthopedics
Background:
- Limited data exist on the relationship between bone turnover and microarchitecture in men.
- Understanding this relationship is crucial for assessing bone health across the male lifespan.
Purpose of the Study:
- To investigate the association between biochemical markers of bone turnover (BTM) and bone microarchitecture in a large cohort of men aged 19-85 years.
- To determine how this association changes with age.
Main Methods:
- High-resolution peripheral quantitative computed tomography (HR-pQCT) was used to assess bone microarchitecture at the distal radius and tibia.
- Serum and urinary biochemical markers of bone formation and resorption were measured.
- Statistical analyses were performed to correlate BTM levels with microarchitectural parameters across different age groups.
Main Results:
- BTM levels were highest in young men, decreasing until age 50, with a subsequent increase in urinary deoxypyridinoline (DPD) after age 70.
- Before age 50, only cortical volumetric bone mineral density (D(cort)) showed a negative correlation with BTM.
- After age 70, higher BTM levels were significantly associated with reduced cortical thickness, D(cort), and altered trabecular microarchitecture (lower Tb.N and Tb.Th) at both skeletal sites.
Conclusions:
- Bone microarchitecture in men is weakly influenced by current bone turnover rates until age 70.
- Beyond age 70, bone turnover emerges as a significant determinant of deteriorating bone microarchitecture, impacting both cortical and trabecular bone.
- These findings highlight age-dependent changes in bone remodeling and their structural consequences in men.
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