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Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
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Gender difference in patients with recurrent neurally mediated syncope.

Jungwae Park1, Shin Yi Jang, Hye Ran Yim

  • 1Division of Cardiology, Department of Medicine, 2Pediatrics Cardiac and Vascular Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul.

Yonsei Medical Journal
|May 26, 2010
PubMed
Summary

Female patients experience neurally mediated syncope (NMS) longer and more frequently than males. While males have more micturition syncope, females experience more defecation syncope.

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Area of Science:

  • Cardiology
  • Neurology
  • Clinical Medicine

Background:

  • Neurally mediated syncope (NMS) is a common condition, but gender-specific differences in clinical presentation are not well-established.
  • Understanding these differences is crucial for accurate diagnosis and management.

Purpose of the Study:

  • To investigate and define gender-based variations in clinical manifestations of NMS.
  • To compare the frequency and characteristics of syncopal episodes between male and female patients.

Main Methods:

  • Retrospective review of medical records from 1,051 patients diagnosed with NMS via head-up tilt test (HUT).
  • Analysis of patient demographics, duration of syncope, frequency of episodes, and specific situational triggers.

Main Results:

  • Female patients reported longer durations of syncope (8.2 years vs. 6.8 years) and a higher number of pre-HUT syncopal episodes (7.2 vs. 5.0) compared to males.
  • Micturition syncope was more prevalent in males (20.0% vs. 5.2%), whereas defecation syncope was more common in females (16.3% vs. 9.3%).

Conclusions:

  • Significant gender differences exist in the clinical presentation of NMS.
  • Females experience syncope for longer periods and more frequently, with distinct situational triggers compared to males.