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Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
Published on: February 14, 2014
Airways oxidative stress, lung function and cognitive impairment in aging
C Gramiccioni1, G E Carpagnano, A Spanevello
1Institute of Respiratory Disease, Department of Medical and Occupational Sciences, University of Foggia, Italy.
Summary
Oxidative stress increases with age, negatively impacting lung function and contributing to depression symptoms. This study highlights the link between aging, oxidative stress, and cognitive health in healthy adults.
Area of Science:
- Gerontology
- Pulmonology
- Neuroscience
Background:
- Oxidative stress, an imbalance of oxidants and antioxidants, is implicated in age-dependent disorders.
- Investigating age-related oxidative stress in airways is crucial for understanding aging processes.
- Non-invasive methods are needed to assess local and systemic oxidative stress.
Purpose of the Study:
- To investigate age-related oxidative stress in airways using non-invasive techniques.
- To evaluate the correlation between systemic and local oxidative stress in different age groups.
- To analyze the relationship between oxidative stress, lung function, and cognitive impairment.
Main Methods:
- Thirty healthy subjects were divided into three age groups (<35, 35-60, >60 years).
- Measurements included oxygen free radicals (diacron reactive oxygen metabolites test) and exhaled nitric oxide.
- Lung function tests and cognitive scales (MMSE, GDS) were administered.
Main Results:
- Older subjects showed increased oxygen free radicals, exhaled nitric oxide, and Geriatric Depression Scale scores.
- Forced expiratory volume in 1 second and forced expiratory vital capacity decreased with age.
- Positive correlations were found between oxidative stress markers and depression scores, and negative correlations with lung function.
Conclusions:
- Progressive local oxidative stress plays a role in age-related decline of lung function.
- Increased oxidative stress is associated with the development of depression symptoms in aging individuals.
- These findings underscore the impact of oxidative stress on respiratory and mental health in the elderly.
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