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Related Concept Videos

Atomic Force Microscopy01:08

Atomic Force Microscopy

Atomic force microscopy (AFM) is a type of scanning probe microscopy that can analyze topographic details of various specimens like ceramics, glass, polymers, and biological samples. AFM offers over 1000 times more resolution than the optical imaging system. Images generated from AFM are three-dimensional surface profiles, offering an advantage over the flat, two-dimensional images from other imaging techniques.
The AFM Probe
The probe is regarded as the heart of any AFM setup and comprises the...

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Probing the Structure and Dynamics of Interfacial Water with Scanning Tunneling Microscopy and Spectroscopy
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Probing the Structure and Dynamics of Interfacial Water with Scanning Tunneling Microscopy and Spectroscopy

Published on: May 27, 2018

Visualizing water molecule distribution by atomic force microscopy.

Kenjiro Kimura1, Shinichiro Ido, Noriaki Oyabu

  • 1Department of Electronic Science and Engineering, Kyoto University, Katsura, Nishikyo, Kyoto 615-8510, Japan. kimura@gold.kobe-u.ac.jp

The Journal of Chemical Physics
|May 27, 2010
PubMed
Summary

Researchers visualized local hydration structures at biomolecule surfaces using atomic force microscopy. This technique revealed packed surface hydration layers at biomolecule/buffer interfaces, offering insights into biofunction and stability.

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Sub-nanometer Resolution Imaging with Amplitude-modulation Atomic Force Microscopy in Liquid
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Related Experiment Videos

Last Updated: Jun 12, 2026

Probing the Structure and Dynamics of Interfacial Water with Scanning Tunneling Microscopy and Spectroscopy
10:28

Probing the Structure and Dynamics of Interfacial Water with Scanning Tunneling Microscopy and Spectroscopy

Published on: May 27, 2018

Sub-nanometer Resolution Imaging with Amplitude-modulation Atomic Force Microscopy in Liquid
10:25

Sub-nanometer Resolution Imaging with Amplitude-modulation Atomic Force Microscopy in Liquid

Published on: December 20, 2016

Area of Science:

  • Surface science
  • Biophysics
  • Materials science

Background:

  • Hydration structures at biomolecular surfaces are critical for understanding biomolecule function and stability.
  • Current methods for analyzing these structures have limitations.

Purpose of the Study:

  • To demonstrate a novel method for measuring local hydration structures at interfaces.
  • To visualize site-specific hydration structures at the muscovite mica/water interface.
  • To analyze hydration layers at biomolecule/buffer solution interfaces.

Main Methods:

  • Utilized an atomic force microscopy (AFM) system equipped with a low-noise deflection sensor.
  • Applied the AFM method to study the muscovite mica/water interface.
  • Investigated the biomolecule/buffer solution interface.

Main Results:

  • Successfully visualized site-specific hydration structures at the muscovite mica/water interface.
  • Identified surface hydration layers at the biomolecule/buffer solution interface.
  • Observed that these surface hydration layers are more packed than those at the muscovite mica/water interface.

Conclusions:

  • The developed AFM method enables visualization of local hydration structures at interfaces.
  • Site-specific hydration structures exist on crystal surfaces.
  • Biomolecule surfaces exhibit densely packed hydration layers crucial for their stability and function.