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Updated: Jun 12, 2026

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
Published on: July 25, 2013
On morphological selection rule of noisy character applied to model (dis)orderly protein formations
Jacek Siódmiak1, Ivan Santamaría-Holek, Adam Gadomski
1Department of Modeling of Physicochemical Processes, Institute of Mathematics and Physics, University of Technology and Life Sciences, Kaliskiego 7, Bydgoszcz 85-796, Poland. siedem@utp.edu.pl
Abstract:
We propose that the main mechanism controlling the selection rule of model (dis)orderly protein formations, such as non-Kossel crystal growth and aggregation of lysozyme from aqueous solution, is an ion-channeling filter having flicker-noise properties. This filter is originated at the interfaces between growing solidlike object and its external liquid-type phase, and it can be considered as a series of voltage gated ion subchannels. The dynamics of each channel is studied by using both simulation and analytic argumentation lines, and represents a novel thought on how to utilize the presence of constructive-noise sources in protein formation, a field of utmost experimental and technological interest.
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