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Optimal Lentivirus Production and Cell Culture Conditions Necessary to Successfully Transduce Primary Human Bronchial Epithelial Cells
Published on: July 22, 2016
Viral bronchiolitis for the clinician.
1Department of Respiratory Medicine, The Children's Hospital at Westmead, Westmead, New South Wales, Australia. dominif2@chw.edu.au
Journal of Paediatrics and Child Health
|May 27, 2010
Summary
Viral bronchiolitis, often caused by respiratory syncytial virus (RSV), is a common infant illness. Most cases resolve at home, but severe cases require hospitalization for hydration and oxygen support.
Area of Science:
- Pediatrics
- Infectious Diseases
- Respiratory Medicine
Background:
- Viral bronchiolitis is a frequent pediatric respiratory infection, predominantly affecting infants under two years old.
- Respiratory syncytial virus (RSV) is the primary causative agent in approximately 95% of infant cases.
- While typically self-limiting, bronchiolitis is a leading cause of hospital admission in infants, with a small percentage requiring intensive care.
Purpose of the Study:
- To review the clinical management and outcomes of viral bronchiolitis in infants.
- To highlight the role of respiratory syncytial virus in severe bronchiolitis cases requiring hospitalization.
- To discuss current treatment strategies and their limitations.
Main Methods:
- Literature review of viral bronchiolitis epidemiology and management.
- Analysis of hospitalization and intensive care unit admission rates.
- Summary of etiological agents, focusing on respiratory syncytial virus.
Main Results:
- Approximately 1% of infants with bronchiolitis are hospitalized, and 10% of those require intensive care.
- Respiratory syncytial virus is identified in about 70% of hospitalized infants.
- Hospital management focuses on supportive care, primarily ensuring adequate hydration and oxygenation.
Conclusions:
- Viral bronchiolitis is a significant cause of infant hospitalization, with RSV being the most common pathogen.
- Current hospital treatments emphasize supportive care; pharmacological interventions have limited proven efficacy.
- Further research may be needed to identify effective treatments to alter the disease course or long-term risks like wheezing.
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