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Trends in quantitative cancer risk assessment
1Biomedical and Environmental Assessment Division, Brookhaven National Laboratory, Upton, NY 11973.
Environmental Health Perspectives
|January 1, 1991
Summary
Quantitative cancer risk assessment is evolving with biomedical research. Key advancements include biologically based models, uncertainty treatment, susceptibility, decision support systems, and risk communication.
Area of Science:
- Quantitative cancer risk assessment
- Biomedical research
Background:
- The field of quantitative cancer risk assessment is rapidly advancing.
- It is increasingly integrated with cutting-edge biomedical research.
Purpose of the Study:
- To identify and describe six key areas of change and growth in quantitative cancer risk assessment.
- To highlight the dynamic nature of the field and its evolving methodologies.
Main Methods:
- Review and synthesis of current trends in cancer risk assessment.
- Identification of six distinct areas of development within the field.
Main Results:
- Expansion of models from cancer initiation to the total carcinogenic process.
- Shift from curve-fitting to biologically based models.
- Movement from upper-bound to best-estimate risk predictions with uncertainty analysis.
- Increased focus on individual susceptibility factors.
- Development of expert systems and decision support tools.
- Growing emphasis on effective risk communication strategies.
Conclusions:
- Quantitative cancer risk assessment is a dynamic and expanding field.
- Methodologies are becoming more biologically relevant, data-driven, and comprehensive.
- The field is increasingly incorporating individual variability and decision-support tools, alongside improved risk communication.
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