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Updated: Jun 12, 2026

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens
Published on: February 14, 2011
Monoclonal antibodies directed against the drug haloperidol
1Department of Biochemistry, The Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, U.K.
Abstract:
Haloperidol coupled to albumin via the hydroxyl or carbonyl group has been used to obtain two classes of monoclonal anti-haloperidol antibodies. Both classes of monoclonal antibody bind haloperidol with high affinity but whereas one class is highly specific for haloperidol the other class binds other butyrophenones e.g. droperidol, spiperone. Anti-idiotypic antisera have been obtained that inhibit [(3)H]haloperidol binding to the anti-haloperidol antibodies but these do not cross react with the D(2) dopamine receptor.
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