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Neuronal growth factors: lessons from nonneural tissues

D C Spray1, P Meda

  • 1Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, U.S.A.

Neurochemistry International
|May 27, 2010
PubMed
Summary

No abstract available in PubMed .

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

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