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[MicroRNA profiling in patients with hepatocellular carcinoma]

Chuan-xi Wang1, Wei Song, Zeng-jun Li

  • 1Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. chuanxiwang@126.com

Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University
|May 27, 2010
PubMed
Abstract

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...