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[Protective effect of polydatin on a PC12 cell model of oxygen-glucose deprivation]
Bing Xu1, Huan-bing Lin, Heng Zhou
1Department of Pharmacology, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Objective:
To evaluate the protective effect of polydatin on a PC12 cell model of oxygen and glucose deprivation (OGD).
Methods:
A pheochromocytoma cell injury model was induced by OGD to simulate the cerebral ischemic changes. The protective effects of polydatin were investigated in this model.
Results:
Polydatin treatment significantly enhanced the cell viability and reduced the levels of lactate dehydrogenase, nitric oxide and the malondialdehyde of the pheochromocytoma cells as compared with the OGD group. Polydatin also increased the activity of superoxide dismutase in the cells.
Conclusion:
Polydatin offers protective effect against OGD-induced injury in pheochromocytoma cells.
