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Updated: Jun 12, 2026
Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
Published on: September 9, 2020
[Diagnostic value of bone marrow biopsy for bone marrow metastatic tumor with unknown primary tumor site]
Ying Wu1, Li-qing Yao, Jie Cheng
1Department of Hematology, Fuzhou General Hospital of Nanjing Comman, Fuzhou 350025, China. zzjian1964@sohu.com
Objective:
To explore the diagnostic value of bone marrow biopsy for bone marrow metastatic tumor with unknown primary tumor site.
Methods:
Thirty-eight cases of metastatic bone marrow tumors were diagnosed by light microscopy, and the bone marrow samples from these cases with unknown primary tumor sites were examined by immunohistochemistry.
Results:
In all the cases, the bone marrow was infiltrated by tumor cells between the bone trabecula. Twenty patients were identified to have poorly differentiated adenocarcinomas, 6 had mucinous adenocarcinomas, 6 had mucinous carcinomas, 4 had poorly differentiated squamous cell carcinomas, and 2 had melanoma. Immunohistochemistry identified the primary tumor sites in these cases, including 12 stomach cancers, 10 breast cancers, 8 prostate cancers, 4 lung cancers, 1 dorsal melanoma, 1 left foot melanoma, and 2 nasopharyngeal cancers.
Conclusion:
Proper immunohistochemistry can help determine the primary tumor sites in patients with metastatic bone marrow tumor with unknown primary tumor sites.
