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Urinary tract pathogens and resistance pattern

R Chakupurakal1, M Ahmed, D N Sobithadevi

  • 1Department of Paediatrics, Burton Hospitals NHS Foundation Trust, Queen's Hospital, Burton-upon-Trent, Staffordshire, UK.

Journal of Clinical Pathology
|May 27, 2010
PubMed

Insights

Pediatric urinary tract infections show increasing resistance to trimethoprim and Augmentin. Antibiotic choice for UTIs should be guided by local resistance data to ensure effective treatment.

Area of Science:

  • Pediatric infectious diseases
  • Antimicrobial resistance
  • Urology

Background:

  • Paediatric urinary tract infections (UTIs) exhibit significant regional variations in bacterial epidemiology and resistance patterns.
  • Antibiotic resistance is evolving, necessitating updated treatment guidelines for effective empiric therapy.

Purpose of the Study:

  • To retrospectively analyze antibiotic resistance patterns in children diagnosed with culture-proven UTIs.
  • To evaluate trends in resistance to commonly prescribed antibiotics over a six-year period.

Main Methods:

  • Inclusion of all infants and children with culture-proven UTI between 2002 and 2008.
  • Positive urine culture defined as pure growth of a single organism >10^5 CFU/mL.

Main Results:

  • A total of 547 UTIs were identified in 337 patients.
  • Escherichia coli (E. coli) was the predominant pathogen, accounting for 92% of cases.
  • A significant increase in resistance was observed for trimethoprim and Augmentin from 2002 to 2008, while resistance to cefalexin and nitrofurantoin remained low.

Conclusions:

  • Increasing resistance to first-line antibiotics (trimethoprim, Augmentin) against E. coli in paediatric UTIs is evident.
  • Regional monitoring of urinary pathogen resistance patterns is crucial for guiding antibiotic selection, adhering to NICE guidance.
  • Further multi-center studies in the UK are needed to validate these findings.
Abstract

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