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Related Concept Videos

Computed Tomography01:10

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Understanding the cancer-CT conundrum.

Thomas R Goodman1

  • 1Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT 06510, USA. rob.goodman@yale.edu

Journal of Clinical Gastroenterology
|May 27, 2010
PubMed
Summary
This summary is machine-generated.

Clinicians must understand computed tomography (CT) risks and radiation-induced malignancy. This review covers CT radiation exposure, biologic effects, and control mechanisms for informed patient discussions.

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Area of Science:

  • Medical Imaging
  • Radiology
  • Radiation Oncology

Background:

  • Computed tomography (CT) is a widely used diagnostic imaging modality.
  • Increasing use of CT has led to concerns about cumulative radiation exposure.
  • Understanding radiation risks is crucial for patient safety and informed consent.

Purpose of the Study:

  • To review the historical growth of ionizing radiation exposure in diagnostic imaging.
  • To explain the biologic effects of radiation exposure.
  • To define the increase in CT radiation in the U.S. and explore exposure control mechanisms.

Main Methods:

  • Literature review of radiation exposure trends.
  • Summary of radiobiology principles.
  • Analysis of CT radiation dose data in the United States.
  • Exploration of radiation dose reduction strategies.

Main Results:

  • Diagnostic imaging, particularly CT, has significantly increased overall ionizing radiation exposure.
  • Ionizing radiation can have detrimental biologic effects, including an increased risk of malignancy.
  • CT accounts for a substantial portion of radiation exposure from diagnostic imaging in the U.S.
  • Various methods exist to control and reduce patient radiation exposure during CT scans.

Conclusions:

  • Clinicians need a thorough understanding of the link between CT imaging and malignancy risk.
  • Informed discussions with patients and radiologists regarding radiation risks are essential.
  • Implementing strategies to control excessive radiation exposure is critical for patient safety.