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Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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Cancers Originate from Somatic Mutations in a Single Cell02:21

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Rous Sarcoma Virus (RSV) and Cancer01:03

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...

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Related Experiment Video

Updated: Jun 12, 2026

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor
09:33

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Familial risks in nervous system tumours: joint Nordic study.

K Hemminki1, S Tretli, J H Olsen

  • 1Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. k.hemminki@dkfz.de

British Journal of Cancer
|May 27, 2010
PubMed
Summary

Familial nervous system tumors show increased risks, especially for peripheral nerve tumors in multiplex families. These findings highlight the importance of genetic counseling for families with a history of nervous system cancers.

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Area of Science:

  • Neuro-oncology
  • Cancer genetics
  • Epidemiology

Background:

  • Familial nervous system cancers are rare, with limited data on site-specific tumor risks.
  • Understanding familial aggregation is crucial for genetic counseling and research.

Purpose of the Study:

  • To analyze familial risks for nervous system tumors across different sites.
  • To identify specific risk patterns in relation to affected relatives and tumor types.

Main Methods:

  • Utilized data from five Nordic countries for a population-based study.
  • Calculated standardized incidence ratios (SIRs) comparing offspring of affected versus non-affected relatives.

Main Results:

  • Elevated SIRs observed for brain, spinal, and peripheral nerve tumors in offspring with affected relatives.
  • Peripheral nerve tumors showed exceptionally high SIRs (up to 943.9) in multiplex families.
  • Spinal tumor risks were significantly higher for offspring of early-onset cases.

Conclusions:

  • Demonstrated site-, proband-, and age-specific risks for familial nervous system tumors.
  • Results have implications for clinical genetic counseling and identifying genetic predispositions.
  • Highlights the need for further research into the genetic underpinnings of familial nervous system cancers.