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Cefoperazone sodium impregnated polycaprolactone composite implant for osteomyelitis
A Anand1, R Pundir, C S Pandian
1Babu Banarasi Das National Institute of Technology & Management, Lucknow-226 007, India.
Indian Journal of Pharmaceutical Sciences
|May 27, 2010
Summary
This study developed a novel biodegradable implant for chronic osteomyelitis, delivering cefoperazone sodium effectively for two months. The implant demonstrated significant microbiological efficacy against Staph. aureus, offering a promising treatment alternative.
Area of Science:
- Biomaterials Science
- Pharmacology
- Orthopedic Surgery
Background:
- Chronic osteomyelitis requires effective local antibiotic delivery.
- Biodegradable implants offer advantages over traditional methods, including high local drug concentration and no need for removal.
- Current treatments face challenges with systemic side effects and achieving sustained therapeutic levels.
Purpose of the Study:
- To develop and evaluate a composite biodegradable implantable delivery system for cefoperazone sodium.
- To assess the implant's physical, chemical, and microbiological properties for treating chronic osteomyelitis.
- To investigate the sustained release of cefoperazone sodium from a calcium sulfate and polycaprolactone composite.
Main Methods:
- A modified fabrication technique was used to create calcium sulfate and polycaprolactone composite implants containing cefoperazone sodium, avoiding solvent use.
- In vitro evaluations included dimensional analysis, hardness, tensile strength, drug release kinetics, and sterility testing.
- Scanning electron microscopy (SEM) assessed morphological changes, and microbiological efficacy was determined against Staph. aureus.
Main Results:
- The developed composite implants exhibited regular shape and size with adequate tensile strength.
- In vitro drug release studies showed cefoperazone sodium levels remained above the minimum inhibitory concentration (MIC) for up to two months.
- Microbiological testing demonstrated a significant zone of inhibition against Staph. aureus, outperforming plain drug solutions.
Conclusions:
- The calcium sulfate and polycaprolactone composite implant is a viable system for sustained local delivery of cefoperazone sodium.
- The implant effectively treats chronic osteomyelitis by maintaining therapeutic antibiotic levels and exhibiting potent antimicrobial activity.
- This biodegradable delivery system presents an attractive alternative for managing osteomyelitis, potentially reducing complications and improving patient outcomes.