Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Tumor mutational burden standardization initiatives: Recommendations for consistent tumor mutational burden assessment in clinical samples to guide immunotherapy treatment decisions.

Genes, chromosomes & cancer·2019

Same author

Ensemble-based network aggregation improves the accuracy of gene network reconstruction.

PloS one·2014

Same author

Developing precision medicine in a global world.

Clinical cancer research : an official journal of the American Association for Cancer Research·2014

Same author

Comparing statistical methods for constructing large scale gene networks.

PloS one·2012

Same author

Probe mapping across multiple microarray platforms.

Briefings in bioinformatics·2011

Same author

Achieving the goals of effective, safe, and individualized cancer care.

Clinical cancer research : an official journal of the American Association for Cancer Research·2011

Same journal

Clinical Significance of Disseminated Pluripotent Tumor Cell Signature Expression in the Bone Marrow from Patients with Colorectal Cancer.

Journal of cancer science & therapy·2021

Same journal

Role of Oxygen and Nitrogen Radicals in the Mechanism of Anticancer Drug Cytotoxicity.

Journal of cancer science & therapy·2020

Same journal

Cisplatin-Based Chemotherapy of Human Cancers.

Journal of cancer science & therapy·2020

Same journal

Nitric oxide: Friend or Foe in Cancer Chemotherapy and Drug Resistance: A Perspective.

Journal of cancer science & therapy·2019

Same journal

Blocking PD1/PDL1 Interactions Together with MLN4924 Therapy is a Potential Strategy for Glioma Treatment.

Journal of cancer science & therapy·2018

Same journal

Advances in NKT cell Immunotherapy for Glioblastoma.

Journal of cancer science & therapy·2018

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 12, 2026

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

Model-Based Background Correction (MBCB): R Methods and GUI for Illumina Bead-array Data.

Jeffrey D Allen¹, Min Chen, Yang Xie

¹Department of Computer Science and Engineering, Southern Methodist University, Dallas, TX, 75205, USA.

Journal of Cancer Science & Therapy

|May 27, 2010

Summary

This summary is machine-generated.

The MBCB R package improves microarray data analysis for Illumina BeadArray cancer research. Its model-based methods offer more precise gene expression determination than traditional approaches.

More Related Videos

Assembly and Tracking of Microbial Community Development within a Microwell Array Platform

Assembly and Tracking of Microbial Community Development within a Microwell Array Platform

Published on: June 6, 2017

Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization

Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization

Published on: August 5, 2008

Related Experiment Videos

Last Updated: Jun 12, 2026

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

Assembly and Tracking of Microbial Community Development within a Microwell Array Platform

Assembly and Tracking of Microbial Community Development within a Microwell Array Platform

Published on: June 6, 2017

Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization

Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization

Published on: August 5, 2008

Area of Science:

Bioinformatics
Genomics
Cancer Research

Background:

Illumina BeadArray technology is widely used in cancer research.
Existing background correction methods in BeadStudio software have limitations.
Model-based approaches offer potential improvements for microarray data analysis.

Purpose of the Study:

To introduce MBCB, an R package for pre-processing Illumina BeadArray data.
To provide statistically efficient normalization and background correction methods.
To enhance the precision and biological interpretation of gene expression data.

Main Methods:

MBCB utilizes model-based statistical methods for background correction.
The package processes summarized bead-type data.
Comparison with Robust multi-array (RMA) and Illumina's default methods was performed.

Main Results:

MBCB demonstrated more precise gene expression determination compared to existing methods.
The package facilitates better biological interpretation of Illumina BeadArray data.
Model-based background correction significantly improved upon traditional methods.

Conclusions:

MBCB offers a statistically robust and efficient solution for Illumina BeadArray data analysis.
The software is expected to advance molecular biomedical and cancer research.
Improved data analysis leads to more accurate biological insights.