Related Experiment Video
Updated: Jun 12, 2026
Chemoselective Preparation of 1-Iodoalkynes, 1,2-Diiodoalkenes, and 1,1,2-Triiodoalkenes Based on the Oxidative Iodination of Terminal Alkynes
Published on: September 12, 2018
Conversion of carbonyl compounds to alkynes: general overview and recent developments
Damien Habrant1, Vesa Rauhala, Ari M P Koskinen
1Laboratory of Organic Chemistry, Aalto University School of Science and Technology, PO Box 16100, FIN-00076 Aalto, Finland.
Synthesize alkynes from carbonyl compounds using one-carbon homologation. This review covers methods, scope, limitations, and applications for creating internal and terminal acetylenic compounds.
Area of Science:
- Organic Chemistry
- Synthetic Chemistry
Background:
- Carbonyl compounds are versatile starting materials.
- One-carbon homologation is a key synthetic strategy.
- Acetylenic compounds have diverse applications.
Purpose of the Study:
- To review methods for synthesizing alkynes from carbonyl compounds.
- To discuss the scope and limitations of these methods.
- To highlight recent developments and applications.
Main Methods:
- Overview of various one-carbon homologation techniques.
- Analysis of reaction mechanisms and conditions.
- Compilation of literature examples.
Main Results:
- Several efficient methods for alkyne synthesis from carbonyls exist.
- Methods vary in substrate scope and functional group tolerance.
- Recent advancements have expanded applicability.
Conclusions:
- One-carbon homologation is a powerful tool for alkyne synthesis.
- The reviewed methods offer flexibility for constructing acetylenic compounds.
- These transformations are valuable in complex molecule synthesis.
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