Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Signaling Molecules01:32

Types of Signaling Molecules

In multicellular organisms, many molecules transmit signals between cells to pass information. These signals vary in complexity and include small peptides, nucleotides, steroids, fatty acid derivatives, and dissolved gases such as nitric oxide. Some signaling molecules diffuse through the plasma membrane to act locally between neighboring cells or travel long distances. Others remain attached to the cell surface, transmitting information to other cells only when they make contact. In some...
Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Overview of Cell Signaling01:23

Overview of Cell Signaling

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inhalation exposure to surrogate military burn pit emissions impairs systemic microvascular function: linking pulmonary insult and diverse peripheral responses.

Particle and fibre toxicology·2026
Same author

CD163 protects against pulmonary injury and inflammation induced by acute O<sub>3</sub> exposure.

bioRxiv : the preprint server for biology·2026
Same author

Repeated air pollution exposure predisposes to adverse outcomes from acute lung injury.

Particle and fibre toxicology·2026
Same author

Toll-like receptor 5 protects against murine lung fibrosis through reduced dysbiosis, and <i>TLR5</i> deficiency is associated with human IPF.

Science translational medicine·2026
Same author

Airborne particulate matter enhances with monosodium urate crystals the secretion of IL-1β by human immune cells.

medRxiv : the preprint server for health sciences·2026
Same author

Endogenous Glucocorticoids Moderate the Gastric Inflammatory Response to Helicobacter Infection and Protect from Autoimmunity.

Cellular and molecular gastroenterology and hepatology·2025

Related Experiment Video

Updated: Jun 12, 2026

Biofunctionalization of Magnetic Nanomaterials
06:40

Biofunctionalization of Magnetic Nanomaterials

Published on: July 16, 2020

Nanoparticles: molecular targets and cell signalling.

Francelyne Marano1, Salik Hussain, Fernando Rodrigues-Lima

  • 1Unit of Functional and Adaptive Biology CNRS EAC, Laboratory of Molecular and Cellular Responses to Xenobiotics, Université Paris Diderot, Paris, France. marano@univ-paris-diderot.fr

Archives of Toxicology
|May 27, 2010
PubMed
Summary

Nanoparticles (NPs) trigger cellular signaling pathways, including MAP kinase cascades and transcription factors, impacting cell cycle and apoptosis. Understanding these NP-cell interactions is crucial, as oxidative stress alone doesn't fully explain NP toxicity mechanisms.

More Related Videos

Solid Lipid Nanoparticles (SLNs) for Intracellular Targeting Applications
08:19

Solid Lipid Nanoparticles (SLNs) for Intracellular Targeting Applications

Published on: November 17, 2015

Harmonic Nanoparticles for Regenerative Research
09:23

Harmonic Nanoparticles for Regenerative Research

Published on: May 1, 2014

Related Experiment Videos

Last Updated: Jun 12, 2026

Biofunctionalization of Magnetic Nanomaterials
06:40

Biofunctionalization of Magnetic Nanomaterials

Published on: July 16, 2020

Solid Lipid Nanoparticles (SLNs) for Intracellular Targeting Applications
08:19

Solid Lipid Nanoparticles (SLNs) for Intracellular Targeting Applications

Published on: November 17, 2015

Harmonic Nanoparticles for Regenerative Research
09:23

Harmonic Nanoparticles for Regenerative Research

Published on: May 1, 2014

Area of Science:

  • Nanotoxicology
  • Cellular Biology
  • Molecular Toxicology

Background:

  • Nanoparticles (NPs) are increasingly linked to diverse cellular outcomes.
  • Oxidative stress is a known factor in NP-induced toxicity, activating pathways like cell cycle arrest and apoptosis.
  • Understanding NP-triggered cellular signaling is essential.

Purpose of the Study:

  • To investigate cellular signaling pathways activated by nanoparticles (NPs).
  • To explore the role of MAP kinase cascades (ERK, p38, JNK) and transcription factors (NFκB, Nrf-2) in NP toxicity.
  • To examine NP interactions with cellular components and their implications for signaling.

Main Methods:

  • Investigated MAP kinase cascades (ERK, p38, JNK).
  • Analyzed redox-sensitive transcription factors (NFκB, Nrf-2).
  • Studied NP interactions with membrane receptors and cellular components.

Main Results:

  • NP interactions with signaling pathways partially explain cytotoxicity.
  • NP-induced apoptosis is closely related to signaling pathway modulation.
  • NPs can interact with membrane receptors, modulating cell signaling and affecting neighboring cells.

Conclusions:

  • Oxidative stress is insufficient to explain all NP-induced mechanisms.
  • New findings necessitate revising the paradigm of oxidative stress in NP toxicity.
  • Further research on NP-cell interactions is vital for understanding NP effects and for cancer therapy applications.