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Related Concept Videos

Endocarditis I: Introduction01:25

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Pneumothorax-I01:26

Pneumothorax-I

A pneumothorax is a condition where air builds up in the space between the lung and the chest wall, causing the lung to collapse. This condition arises when air enters the space between the parietal and visceral pleura, disrupting the negative pressure essential for lung inflation. This can lead to a partial or complete collapse of the lung.
Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:

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Related Experiment Video

Updated: Jun 12, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

[Sepsis and heart].

H Ebelt1, K Werdan

  • 1Klinik und Poliklinik für Innere Medizin III, Universitätsklinikum Halle (Saale), Ernst-Grube-Strasse 40, Halle, Germany. henning.ebelt@medizin.uni-halle.de

Der Internist
|May 27, 2010
PubMed
Summary
This summary is machine-generated.

Severe sepsis impairs heart function, reducing ejection fraction and heart rate variability. Endotoxin and autonomic nervous system interactions contribute to these cardiac issues, impacting patient prognosis.

Related Experiment Videos

Last Updated: Jun 12, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

Area of Science:

  • Cardiology
  • Critical Care Medicine
  • Pathophysiology

Context:

  • Severe sepsis and septic shock frequently cause cardiac dysfunction.
  • Impaired heart rate variability in sepsis correlates with poor prognosis.
  • Endotoxin is implicated in the link between inflammation and altered heart rate regulation.

Purpose:

  • To explore the mechanisms of septic cardiomyopathy.
  • To understand the role of endotoxin, cardiac pacemaker current I(f), and the autonomic nervous system in sepsis-induced cardiac dysfunction.
  • To review current methods for quantifying septic cardiomyopathy and the outcomes of therapeutic interventions.

Summary:

  • Sepsis leads to cardiac impairment, characterized by reduced ejection fraction and heart rate variability.
  • Experimental models show endotoxin influences the cardiac pacemaker current I(f) and autonomic nervous system, increasing heart rate and decreasing variability.
  • Cardiac output relative to systemic vascular resistance is key for assessing septic cardiomyopathy, though clinical trials targeting pathogenesis have yielded disappointing results.

Impact:

  • Highlights the complex interplay of endotoxin, cardiac electrophysiology, and autonomic dysfunction in sepsis.
  • Underscores the prognostic significance of heart rate variability in severe sepsis.
  • Suggests potential benefits of activated protein C, emphasizing the role of microcirculatory changes in septic cardiomyopathy.