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Updated: Jun 12, 2026

Preparation of Thermoresponsive Nanostructured Surfaces for Tissue Engineering
Published on: March 1, 2016
Characterization of ultra-thin temperature-responsive polymer layer and its polymer thickness dependency on cell
Kazuhiro Fukumori1, Yoshikatsu Akiyama, Yoshikazu Kumashiro
1Department of Applied Chemistry, Waseda University, 3-4-1 Ohkubo, Shinjuku, Tokyo, Japan.
Abstract:
Ultra thin poly(N-isopropylacrylamide) (PIPAAm) modified glass coverslips (PIAPAm-CS) using electron beam irradiation exhibited a clear relationship between the polymer thickness and thermal cell adhesion/detachment behavior. The polymer thickness dependency and the characteristic of ultra thin PIPAAm layer, has been illustrated in terms of the molecular motion of the modified PIPAAm chains. PIPAAm-CSs surfaces with various area-polymer densities and thicknesses were characterized by AFM and protein adsorption assay. The newly obtained results gave a further insight into the illustration. Finally, the future application of intelligent surfaces was discussed for fabricating tissue and organ.
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