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Hormonal therapy with estradiol and testosterone implants: bone protection?

Renata Britto1, Leila Araújo, Ione Barbosa

  • 1Department of Gynecology, Federal University of Bahia (UFBA), Salvador, Bahia, Brazil. renatalopesbritto@gmail.com

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
|May 28, 2010
PubMed
Summary

Hormonal implants combining estradiol and testosterone helped protect bone mineral density (BMD) in postmenopausal women. This study compared women with implants to those without, finding a protective effect over one year.

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Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Geriatric Medicine

Background:

  • Postmenopausal osteoporosis is a significant health concern.
  • Hormone replacement therapy is a common treatment for menopausal symptoms and bone loss.
  • The combined effects of estradiol and testosterone on bone mineral density (BMD) require further investigation.

Purpose of the Study:

  • To evaluate the impact of estradiol and testosterone hormonal implants on BMD in postmenopausal women.
  • To compare BMD changes in women using hormonal implants versus those not receiving hormonal therapy.

Main Methods:

  • A prospective cohort study involving 61 postmenopausal women.
  • Participants were divided into two groups: Group 1 (34 women with hormonal implants) and Group 2 (27 women without hormonal therapy).
  • Bone mineral density (BMD) was assessed using Dual-energy X-ray absorptiometry at baseline and after one year.

Main Results:

  • In Group 1, lumbar spine BMD showed no significant change (1.123 ± 0.16 to 1.144 ± 0.18 kg/m², p=0.39), and femur BMD showed a trend towards increase (0.922 ± 0.16 to 0.957 ± 0.12 kg/m², p=0.076).
  • In Group 2, lumbar spine BMD slightly decreased (1.064 ± 0.2 to 1.001 ± 0.23 kg/m², p=0.112), and femur BMD significantly decreased (0.928 ± 0.14 to 0.881 ± 0.15 kg/m², p=0.046).
  • Comparison between groups indicated that hormonal implants promoted bone protection.

Conclusions:

  • The combination of estradiol and testosterone in hormonal implants demonstrated a bone-protective effect in postmenopausal women over a one-year period.
  • This finding suggests that combined hormone therapy may be beneficial in preventing bone loss in this population.
  • Further research with longer follow-up periods is warranted to confirm these results.