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Updated: Jun 12, 2026

Assessing Whole-Body Lipid-Handling Capacity in Mice
Published on: November 24, 2020
Concomitant decrease in the elongation and condensation activities of very-long chain fatty acyl-CoA in jimpy mouse
M Takeshita1, S Yoshida, T Yubisui
1Department of Biochemistry, Medical College of Oita, Hazama-cho, Oita 879-56, Japan.
Abstract:
Overall elongation and condensation of long-chain and very-long-chain fatty acids have been studied in the brain microsomes of jimpy mice. Both the elongation and condensation activities with stearoyl (18:0)-, oleoyl (18:1)- and arachidoyl (20:0)-CoA were severely diminished in jimpy brain, but the decrease in the activity with the exogenous palmitoyl (16:0)-CoA was less pronounced. The decrease in the elongation and condensation reactions with endogenous palmitic and arachidonic (20:4) acids was not distinct in the mutant. The decrease in the activity of condensation reaction may be responsible for the reduced rate of overall fatty acid elongation.
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