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Isatin, regional distribution in rat brain and tissues
1Royal Postgraduate Medical School, Institute of Obstetrics and Gynaecology, Department of Chemical Pathology, Queen Charlotte's and Chelsea Hospital, Goldhawk Road, London W6 0XG, England.
Abstract:
Isatin has recently been identified in rat tissues and normal human urine, where it forms the major proportion of the endogenous monoamine oxidase inhibitor, tribulin. In this paper, we show that isatin, measured by gas chromatography/mass spectrometry, has a distinct regional distribution in rat tissues, with highest concentrations in seminal vesicles (1.6 ?g/g) and vas deferens (3.4 ?g/g). There was also a discontinuous distribution within rat brain, concentrations being highest in the hippocampus (0.13 ?g/g).
