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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Antiasthma Drugs: Leukotriene Modifiers01:19

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...

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Related Experiment Video

Updated: Jun 12, 2026

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

Tolerizing allergic responses in the lung.

C M Lloyd1, J R Murdoch

  • 1Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, UK. c.lloyd@imperial.ac.uk

Mucosal Immunology
|May 28, 2010
PubMed
Summary
This summary is machine-generated.

The pulmonary immune system balances responses to pathogens and allergens. Understanding immune tolerance breakdown in asthma may lead to new therapies for allergic diseases.

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Related Experiment Videos

Last Updated: Jun 12, 2026

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation
07:52

Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation

Published on: July 23, 2012

Bronchoalveolar Lavage of Murine Lungs to Analyze Inflammatory Cell Infiltration
07:03

Bronchoalveolar Lavage of Murine Lungs to Analyze Inflammatory Cell Infiltration

Published on: May 4, 2017

Area of Science:

  • Immunology
  • Pulmonary Medicine
  • Allergy Research

Background:

  • The pulmonary immune system must control infections while tolerating harmless inhaled substances.
  • Lung stromal cells and immune cells form a network to maintain this tolerance.
  • A breakdown in tolerance leads to allergic diseases like asthma.

Purpose of the Study:

  • To explore the mechanisms of immune tolerance in the lungs.
  • To understand factors contributing to the loss of tolerance in allergic individuals.
  • To identify potential therapeutic targets for chronic asthma.

Main Methods:

  • This study reviews current understanding of pulmonary immune responses.
  • It examines the interplay between genetic and environmental factors in allergy development.
  • The research synthesizes evidence on immune tolerance mechanisms.

Main Results:

  • Immune tolerance is crucial for preventing inflammatory responses to allergens.
  • Genetic predisposition and early environmental exposures, like pathogens, influence tolerance.
  • Dysregulation of immune tolerance contributes to allergic pathology.

Conclusions:

  • Further research into pulmonary immune tolerance mechanisms is needed.
  • Understanding these mechanisms could reveal novel therapeutic strategies for asthma.
  • Targeting immune tolerance pathways may offer new treatments for allergic respiratory diseases.