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Related Concept Videos

Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...

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Related Experiment Video

Updated: Jun 12, 2026

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation
09:10

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation

Published on: July 27, 2022

Radiation proctitis: a decade's experience.

M T C Wong1, J F Lim, K S Ho

  • 1Department of Colorectal Surgery, Singapore General Hospital, Outram Road, Singapore 169608.

Singapore Medical Journal
|May 28, 2010
PubMed
Summary
This summary is machine-generated.

Radiation proctitis, a common side effect of pelvic radiotherapy, often presents with rectal bleeding. While topical treatments are effective for most, severe cases may require surgery.

Related Experiment Videos

Last Updated: Jun 12, 2026

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation
09:10

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation

Published on: July 27, 2022

Area of Science:

  • Oncology
  • Gastroenterology
  • Radiation Oncology

Background:

  • Pelvic radiotherapy is crucial for treating pelvic malignancies but can cause rectal injury.
  • Radiation proctitis is a significant collateral damage of pelvic radiation therapy.

Purpose of the Study:

  • To analyze the clinical characteristics and treatment outcomes of patients with radiation proctitis.
  • To evaluate the efficacy of different treatment modalities for radiation proctitis.

Main Methods:

  • Retrospective analysis of prospectively gathered patient data over a 10-year period (1995-2004).
  • Inclusion of patient demographics, cancer type, radiotherapy details, symptoms, diagnosis, treatments, and follow-up duration.
  • Analysis of presenting symptoms, latent period, and treatment responses.

Main Results:

  • 77 patients treated for radiation proctitis; median follow-up of 14 months.
  • Most common cancers: gynecological (63.6%), prostate (18.2%), colorectal (15.6%).
  • Rectal bleeding (89.6%) was the primary symptom, with a median latent period of 24 months. Topical formalin was used in 72.5% of cases, often requiring repeat treatments. Surgery was necessary for 18.2% due to intractable bleeding or complications.

Conclusions:

  • Radiation proctitis presents a therapeutic challenge, requiring tailored management.
  • Topical treatments are effective for most cases of rectal bleeding.
  • Surgery remains essential for managing severe or life-threatening symptoms of radiation proctitis.