Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
What is the Skeletal System?01:02

What is the Skeletal System?

Overview
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nonsynthetic platelet-like products: methods and clinical potential in hemorrhage control.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis·2026
Same author

Immunomodulatory Effects of Multi-Strain Probiotic Capsules for Psoriatic Arthritis: A Pilot Double-Blind Randomized Controlled Trial.

Food science & nutrition·2025
Same author

Subgaleal Hematoma in a Female With Normal Coagulation Tests.

Case reports in hematology·2025
Same author

Antiphospholipid antibodies in patients with COVID-19: a systematic review and meta-analysis.

Journal of thrombosis and thrombolysis·2025
Same author

Systemic Lupus Erythematosus Presenting With Autoimmune Myelofibrosis in a Young Woman: A Case Report.

Clinical case reports·2025
Same author

The relationship between dose of methotrexate and incidence of liver fibrosis in patients with rheumatoid arthritis.

Reumatologia·2025

Related Experiment Video

Updated: Jun 12, 2026

Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells
09:46

Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells

Published on: December 27, 2017

Bleeding disorders and reduced bone density.

Hassan Mansouritorghabeh1, Zahra Rezaieyazdi

  • 1Immunology Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, 91766-99199, Mashhad, Iran. Mansouritorghabe@mums.ac.ir

Rheumatology International
|May 28, 2010
PubMed
Summary

Individuals with severe haemophilia A and B face challenges like reduced bone density (RBD). Early detection, treatment, physical activity, and anti-osteoporotic therapy are crucial for managing bone health in bleeding disorders.

Related Experiment Videos

Last Updated: Jun 12, 2026

Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells
09:46

Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells

Published on: December 27, 2017

Area of Science:

  • Hematology
  • Orthopedics
  • Public Health

Background:

  • Improved treatments have increased life expectancy for individuals with severe hemophilia A and B.
  • Emerging concerns include auto-antibody inhibitors and reduced bone density (RBD) in this population.
  • RBD is a growing global health issue, particularly with an aging population affected by bleeding disorders.

Purpose of the Study:

  • To review published literature on bone mineral density (BMD) in individuals with hemophilia A & B.
  • To examine BMD in patients with combined factor V and VIII deficiency and other rare bleeding disorders.
  • To identify key factors and preventive strategies for managing bone health in bleeding disorder patients.

Main Methods:

  • Systematic review of published papers on bone mineral density in bleeding disorders.
  • Analysis of studies focusing on hemophilia A, hemophilia B, combined factor V and VIII deficiency, and other rare bleeding disorders.
  • Synthesis of findings related to BMD and associated risk factors.

Main Results:

  • Reduced bone density (RBD) is a significant concern in individuals with hemophilia and other rare bleeding disorders.
  • The increasing life expectancy and aging population exacerbate the burden of RBD.
  • Data on BMD in combined factor V and VIII deficiency and other rare bleeding disorders require further investigation.

Conclusions:

  • Preventive measures are essential for individuals with bleeding disorders to maintain bone health.
  • Strategies include early detection and treatment, adequate physical activity, sports engagement, and anti-osteoporotic therapy.
  • A proactive approach is necessary to mitigate the impact of reduced bone density in this population.