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Related Experiment Video

Updated: Jun 12, 2026

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

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Published on: July 12, 2018

Genetic polymorphisms among C57BL/6 mouse inbred strains.

Esther Zurita¹, Mónica Chagoyen, Marta Cantero

¹Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB-CSIC), Campus de Cantoblanco, Darwin 3, 28049, Madrid, Spain.

Transgenic Research

|May 28, 2010

Summary

Genetic differences exist among C57BL/6 mouse substrains, impacting their use in research. Identifying these genetic variations is crucial for accurate animal model development and colony management.

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Area of Science:

Genetics
Animal Models
Biotechnology

Background:

C57BL/6 mice are widely used for transgenic and knockout models.
Existing C57BL/6 substrains exhibit genetic and phenotypic variations.
Long-term separation of breeding stocks can lead to accumulated genetic differences.

Purpose of the Study:

To characterize the genetic differences among various C57BL/6 substrains.
To identify informative genetic markers for distinguishing C57BL/6 substrains.

Main Methods:

Utilized the Illumina Mouse Medium Density Linkage Mapping panel.
Analyzed 1,449 single nucleotide polymorphisms (SNPs) across ten C57BL/6-related strains.
Identified twelve informative SNPs for substrain discrimination.

Main Results:

C57BL/6J substrains from different sources were genetically indistinguishable.
All C57BL/6N substrains showed identical genotypes.
Other C57BL/6 substrains displayed intermediate genetic profiles with unique polymorphisms.

Conclusions:

Genetic monitoring of C57BL/6 substrains is essential.
Understanding substrain-specific genetic variations is critical for accurate mouse colony handling.
These findings support the appropriate use of distinct C57BL/6 substrains in research.