Related Experiment Video
Updated: Jun 12, 2026
08:01
Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management
Published on: November 30, 2022
The need for a biological registration system
Todd D Pihl1, Randall K Ribaudo
1Human Workflows LLC, 1 Research Court Suite 450, Rockville, MD 20850, USA.
Idrugs : the Investigational Drugs Journal
|May 28, 2010
Summary
A biological registration system can identify and assign unique identifiers to complex biological molecules. Implementing this system offers enterprise-wide benefits, improving data integration and drug discovery efficiency in pharmaceutical research.
Area of Science:
- Biotechnology
- Pharmaceutical Sciences
- Data Management
Background:
- Biological registration systems are underutilized in the pharmaceutical industry despite their utility for chemists.
- Current data management practices in pharmaceutical R&D often result in siloed information.
- Effective data and knowledge integration are crucial for translational science and systems biology.
Purpose of the Study:
- To review the development of a commercially viable biological registration system tailored for the pharmaceutical industry.
- To highlight the enterprise-wide benefits of implementing such a system, from R&D to laboratory safety.
- To demonstrate how integrated systems can overcome data silos and enhance drug discovery.
Main Methods:
- A collaborative approach involving a special interest group of pharmaceutical companies and a software provider.
- Focus on creating a system capable of determining molecular identity and assigning unique identifiers.
- Integration strategies with existing systems like electronic lab notebooks and inventory databases were considered.
Main Results:
- Development of a commercially viable and supportable biological registration system.
- Demonstration of potential enterprise-wide benefits, including improved R&D, intellectual property management, and lab safety.
- Facilitation of data and knowledge integration across global research institutions.
Conclusions:
- Biological registration systems offer significant advantages for pharmaceutical companies, enhancing efficiency and data integration.
- Collaboration between industry stakeholders and software developers is key to creating effective biological registration solutions.
- Implementing integrated biological registration systems can accelerate drug discovery and advance translational science.
Related Concept Videos
01:28Global Regulatory Systems
Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
01:19Purpose of Health Records II
Health records serve various essential purposes in the healthcare system. Here are some key purposes:
01:11Purpose of Health Records I
The vital purpose of health records is to provide a complete and accurate account of a patient's medical history, including communication, diagnostic and therapeutic orders, care planning, research, and quality review.
Here's a breakdown of how health records serve these purposes:
Here's a breakdown of how health records serve these purposes:
01:28Drug Products: Biologics, Biosimilars and Interchangeables
Biologics, derived from living sources such as humans, animals, or microorganisms, represent a significant category of pharmaceuticals. These complex molecules, developed through advanced biotechnological methods or purified from natural sources, include essential medical treatments like insulin and growth hormones. The complexity of biologics arises from their large molecular structures and the intricate processes required for their production, making them distinct from conventional...
01:24Microbial Classification System
Classification is the process of organizing organisms into hierarchically inclusive groups based on their phenotypic similarities or evolutionary relationships. A species comprises one or more strains, and closely related species are grouped into genera. Genera are further classified into families, families into orders, orders into classes, and so forth, up to the domain level, which is the broadest taxonomic rank derived from a combination of phenotypic and genotypic data.The nomenclature of...
01:25Drug Regulation
Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...