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Updated: Jun 12, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
Published on: August 8, 2022
[CX3CR1 polymorphism in patients with dilated cardiomyopathy]
Xing-qiu He1, Yan-yun Wang, Bin Zhou
1Departmentof Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Objective:
To investigate the association between CX3CR1 gene polymorphism and dilated cardiomyopathy (DCM).
Methods:
Two single nucleotide polymorphisms (SNP) rs3732378 (V249I) and rs3732379(T280M) in CX3CR1 gene were determined using PCR-RFLP. The frequencies of genotype and allele of these two SNPs were compared between 211 DCM patients and 211 normal controls.
Results:
The genotype distribution of these two SNPs had no deviation from Hardy-Weinberg equilibrium either in DCM patients or in the controls. No significant difference was found in the frequencies of genotype and allele in rs3732378 and rs3732379 between the DCM patients and the controls.
Conclusion:
CX3CR1 gene polymorphism is not associated with DCM.
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