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Related Experiment Video

Updated: Jun 12, 2026

Reproductive Techniques for Ovarian Monitoring and Control in Amphibians

Reproductive Techniques for Ovarian Monitoring and Control in Amphibians

Published on: May 12, 2019

Inherited human chorionic gonadotropin.

Laurence A Cole¹, Laura L Laidler

¹USA hCG Reference Service, Department of Obstetrics and Gynecology, MSC10-5580, 1 University of New Mexico, Albuquerque, NM 87131, USA. larry@hcglab.com

The Journal of Reproductive Medicine

|May 29, 2010

Summary

This summary is machine-generated.

Inherited human chorionic gonadotropin (hCG) is a newly identified cause of persistently low hCG levels. This regular hCG is likely produced by the pituitary gland, potentially due to a genetic disorder or excess production.

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Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos

Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos

Published on: June 12, 2020

Area of Science:

Endocrinology
Reproductive Biology
Human Genetics

Background:

Persistent low concentrations of human chorionic gonadotropin (hCG) can be challenging to interpret clinically.
Understanding the source of hCG is crucial for accurate diagnosis and patient management.

Purpose of the Study:

To investigate the cause of persistent low concentrations of human chorionic gonadotropin (hCG) in 405 cases.
To identify novel sources or mechanisms contributing to low hCG levels.

Main Methods:

Utilized the USA hCG Reference Service for analysis.
Measured total regular hCG, follicle stimulating hormone (FSH), and luteinizing hormone (LH) using the Siemens Immulite 1000 assay.
Quantified hyperglycosylated hCG, nicked hCG, C-terminal peptide total hCG, intact regular hCG, free beta-subunit, and beta-core fragment via manual microtiter plate assays.

Main Results:

Identified four cases of inherited hCG.
Observed similar hCG production patterns in first-degree relatives of affected individuals.
Noted that all identified cases primarily produced the regular hCG dimer, with one case showing hCG detection solely in urine.

Conclusions:

Inherited hCG is a newly recognized source of persistent low hCG concentrations.
It is hypothesized that this regular hCG originates from the pituitary gland.
Potential mechanisms include excess pituitary production or a genetic disorder affecting hCG synthesis.