Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Metal-Ligand Bonds02:51

Metal-Ligand Bonds

The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
Complexation Equilibria: The Chelate Effect01:19

Complexation Equilibria: The Chelate Effect

In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
Formation of Complex Ions03:45

Formation of Complex Ions

A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...
Complexation Equilibria: Factors Influencing Stability of Complexes01:09

Complexation Equilibria: Factors Influencing Stability of Complexes

In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...
Noncovalent Attractions in Biomolecules02:35

Noncovalent Attractions in Biomolecules

Noncovalent attractions are associations within and between molecules that influence the shape and structural stability of complexes. These interactions differ from covalent bonding in that they do not involve sharing of electrons.
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...
EDTA: Chemistry and Properties01:22

EDTA: Chemistry and Properties

Polydentate ligands are most widely used in complexometric titrations because they form more stable complexes with the metal ions than mono- or bidentate ligands due to the chelate effect. Examples of polydentate ligands are ethylenediaminetetraacetic acid (EDTA), crown ethers, and cryptands. The most important feature of optimal polydentate ligands is the ability to form 1:1 complexes in a single-step process. Amino carboxylic acid derivatives are frequently used as complexing agents. EDTA is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Validation of Quantum Chemistry Predictions. Quinoidal-Base Tautomers in Anthocyanins and Related Compounds.

The Journal of organic chemistry·2026
Same author

Triphenylene chromophore enhances emission in Au/Cu heterometallic complexes.

Dalton transactions (Cambridge, England : 2003)·2026
Same author

An identified case of poliomyelitis: contribution to diagnosis in ancient human remains.

Anthropological science : journal of the Anthropological Society of Nippon = Jinruigaku zasshi·2026
Same author

Open dataset of femoral cross-sectional geometry across ontogeny, including high resolution CT-derived structural variables, estimated ages, and proteomic sex identification.

Data in brief·2026
Same author

Mucosal melanoma: clinicopathological, molecular and prognostic features in a retrospective cohort.

Virchows Archiv : an international journal of pathology·2026
Same author

Pelvic morphology and body size in relation to the preauricular sulcus: Evidence from medieval to modern Iberia.

Anatomical record (Hoboken, N.J. : 2007)·2026

Related Experiment Video

Updated: Jun 12, 2026

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
11:04

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Published on: September 7, 2019

Specific supramolecular interactions between Zn(2+)-salophen complexes and biologically relevant anions.

Manoli Cano1, Laura Rodríguez, João Carlos Lima

  • 1REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Monte de Caparica, Portugal.

Inorganic Chemistry
|May 29, 2010
PubMed
Summary

Zinc(2+)-salophen complexes selectively recognize nucleotides over inorganic phosphates. Spectroscopic studies reveal specific binding interactions, highlighting their potential as supramolecular receptors for biologically important molecules.

More Related Videos

Thermochemical Studies of Ni(II) and Zn(II) Ternary Complexes Using Ion Mobility-Mass Spectrometry
16:11

Thermochemical Studies of Ni(II) and Zn(II) Ternary Complexes Using Ion Mobility-Mass Spectrometry

Published on: June 8, 2022

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
06:35

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates

Published on: February 15, 2016

Related Experiment Videos

Last Updated: Jun 12, 2026

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
11:04

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Published on: September 7, 2019

Thermochemical Studies of Ni(II) and Zn(II) Ternary Complexes Using Ion Mobility-Mass Spectrometry
16:11

Thermochemical Studies of Ni(II) and Zn(II) Ternary Complexes Using Ion Mobility-Mass Spectrometry

Published on: June 8, 2022

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
06:35

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates

Published on: February 15, 2016

Area of Science:

  • Supramolecular Chemistry
  • Coordination Chemistry
  • Analytical Chemistry

Background:

  • Salophen complexes are versatile ligands with applications in sensing and catalysis.
  • Nucleotides and inorganic phosphates are crucial biomolecules with distinct chemical properties.
  • Selective recognition of these anions is important for biological and chemical analysis.

Purpose of the Study:

  • To investigate the recognition of inorganic phosphates and nucleotides by Zn(2+)-salophen complexes.
  • To elucidate the binding modes and selectivity of these complexes.
  • To explore the potential of these complexes as supramolecular ditopic receptors.

Main Methods:

  • Nuclear Magnetic Resonance (NMR) spectroscopy ((31)P and (1)H)
  • Mass Spectrometry
  • UV-Vis Absorption Spectroscopy
  • Emission Spectroscopy
  • Nanosecond Laser Flash Photolysis

Main Results:

  • Zn(2+)-salophen complexes bind both inorganic phosphates and nucleotides.
  • Nucleotides induce significant changes in spectral properties, unlike phosphates.
  • (1)H NMR confirms the involvement of the adenine aromatic group in nucleotide complexation.
  • Lifetime measurements indicate the formation of 1:0.5 and 1:1 host/guest complexes with nucleotides.

Conclusions:

  • Salophen derivatives act as supramolecular ditopic receptors for nucleotides.
  • The complexes exhibit selectivity towards nucleotides over inorganic phosphates.
  • These findings support the development of novel sensors for biologically relevant molecules.