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Mosquito-Associated Virus Isolation from Field-Collected Mosquitoes
Published on: August 31, 2022
New measles virus genotype associated with outbreak, China
Yan Zhang1, Zhengrong Ding, Huiling Wang
1National Institute for Viral Disease Control and Prevention, Beijing, People's Republic of China.
Emerging Infectious Diseases
|May 29, 2010
Summary
Genetic analysis of a 2009 measles outbreak in China revealed viruses distinct from known strains. These findings suggest a potential new measles genotype, aiding in understanding measles transmission in Southeast Asia.
Area of Science:
- Virology
- Molecular Epidemiology
- Public Health
Background:
- Measles outbreaks pose a significant public health challenge globally.
- Accurate genotyping is crucial for understanding measles virus transmission dynamics.
Purpose of the Study:
- To investigate the genetic origin of measles virus strains from a 2009 outbreak in Menglian County, China.
- To determine the phylogenetic relationship of these strains to existing measles virus genotypes.
Main Methods:
- Phylogenetic analysis using nucleoprotein (N) and hemagglutinin (H) gene sequences.
- Comparison of Menglian virus sequences with World Health Organization (WHO) reference strains and public databases (GenBank, Health Protection Agency Measles Nucleotide Surveillance).
Main Results:
- Menglian viruses showed significant nucleotide divergence (≥3.0%) from all WHO reference strains.
- The Menglian viruses, along with two older non-Menglian viruses, align with a proposed new measles genotype, designated d11.
- This genotype is distinct from the 23 currently recognized measles virus genotypes.
Conclusions:
- The identified measles virus strains likely represent a novel genotype (d11).
- This new genotype designation can improve the description of measles transmission patterns, particularly in the Southeast Asian and Western Pacific regions.
- Further surveillance and genetic characterization are essential for global measles control efforts.
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