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Melanocortin 1 receptor agonists reduce proteinuria

Annika Lindskog1, Kerstin Ebefors, Martin E Johansson

  • 1Department of Molecular and Clinical Nephrology, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. annika.lindskog@wlab.gu.se

Journal of the American Society of Nephrology : JASN
|May 29, 2010
PubMed
Summary

Adrenocorticotropic hormone (ACTH) may reduce proteinuria in membranous nephropathy by activating the melanocortin receptor 1 (MC1R) found in podocytes. MC1R agonists improved kidney function and reduced oxidative stress in nephrotic rats.

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