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Updated: Jun 12, 2026
Corneal Donor Tissue Preparation for Descemet's Membrane Endothelial Keratoplasty
Published on: September 17, 2014
Rate and risk factors for cataract formation and extraction after Descemet stripping endothelial keratoplasty
Marianne O Price1, David A Price, Kelly M Fairchild
1Cornea Research Foundation of America, Indianapolis, IN 46260, USA. marianneprice@cornea.org
Purpose:
To assess the rate and risk factors for cataract formation and extraction after Descemet stripping endothelial keratoplasty (DSEK).
Methods:
An initial, consecutive series of 1050 primary DSEK procedures was reviewed to identify eyes that remained phakic. Only the first-treated eye of each patient was included; 60 eyes qualified. Rate and risk factors for subsequent cataract formation and extraction were assessed by multivariate proportional hazards modelling and survival analysis.
Results:
Median patient age was 52 years (range: 32-69 years), and median graft diameter was 8.5 mm (range: 8-9 mm). Median follow-up was 32 months (range: 1-51 months). Cataract extraction was performed after DSEK in 22 eyes (37%) without complication and all grafts remained clear with median follow-up of 18 months (range: 1-44 months). Six eyes were regrafted; all underwent cataract extraction either simultaneously (n = 4) or subsequently (n = 2). At 1 and 3 years, respectively, the probability of cataract extraction was 0% and 7% in patients who were 50 years or younger at the time of DSEK (n = 20) versus 31% and 55% in older patients (n = 40), a statistically significant difference (p = 0.0005).
Conclusions:
Rates of cataract formation and extraction after DSEK were significantly higher in patients over 50 years of age and substantially exceeded normal population rates.
