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Drug delivery systems. 6. Transdermal drug delivery.

V V Ranade1

  • 1Action Medical Marketing Co. Libertyville, Illinois.

Journal of Clinical Pharmacology
|May 1, 1991
PubMed
Summary

Transdermal drug delivery systems offer controlled, continuous medication release through the skin for systemic treatment. Advances in technology and enhancers enable delivery of diverse therapeutic agents, including large molecules.

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Area of Science:

  • Pharmaceutical Sciences
  • Dermatology
  • Drug Delivery Systems

Background:

  • Transdermal drug delivery systems (TDDS) have evolved from topical creams to sophisticated methods for systemic drug administration.
  • The skin's barrier function, while protective, has historically limited transdermal absorption.
  • Understanding skin impermeability has enabled the development of effective transdermal drug delivery.

Purpose of the Study:

  • To review the evolution and current state of transdermal drug delivery systems.
  • To explore various transdermal system designs and their mechanisms of action.
  • To highlight the expanding range of therapeutic agents suitable for transdermal delivery.

Main Methods:

  • Overview of established transdermal system categories: microsealed, matrix-diffusion, membrane-permeation, and gradient-charged systems.
  • Discussion of advanced transdermal carriers, including iontophoretic, sonophoretic, prodrugs, and liposomes.
  • Examination of chemical penetration enhancers facilitating the delivery of larger molecules.

Main Results:

  • Four primary transdermal systems facilitate drug absorption across the skin.
  • Advanced carriers and penetration enhancers expand the therapeutic potential of transdermal delivery.
  • Numerous drugs, from small molecules to proteins, are being formulated or investigated for transdermal systems.

Conclusions:

  • Transdermal drug delivery offers a viable route for controlled systemic medication.
  • Ongoing research in enhancers and novel carriers broadens the scope of treatable conditions via transdermal routes.
  • The field continues to advance, promising improved therapeutic outcomes and patient compliance.

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