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Related Experiment Videos

Panniculitis in an immunocompromised patient.

A K Silverman1, S C Gilbert, D Watkins

  • 1Psoriasis Center, Baylor University Medical Center, Dallas.

Journal of the American Academy of Dermatology
|May 1, 1991
PubMed
Summary

Histoplasmosis panniculitis developed in a patient receiving steroid therapy for myelodysplasia-induced pancytopenia. This rare skin manifestation of disseminated histoplasmosis is important to consider in immunocompromised patients.

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Area of Science:

  • Medical Mycology
  • Dermatology
  • Hematology

Background:

  • Disseminated histoplasmosis is a systemic fungal infection.
  • Cutaneous manifestations are uncommon but can occur in immunocompromised individuals.
  • Myelodysplastic syndromes (MDS) are a group of clonal hematopoietic stem cell disorders.

Observation:

  • A patient with myelodysplastic syndrome (MDS) developed pancytopenia.
  • The patient was undergoing steroid therapy for pancytopenia.
  • Histoplasmosis panniculitis, a rare skin condition, manifested during treatment.

Findings:

  • Histoplasmosis panniculitis developed in the context of immunosuppression due to steroid therapy for MDS.
  • This case highlights an unusual presentation of disseminated histoplasmosis.

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  • Cutaneous involvement in disseminated histoplasmosis is rare but significant.

    • Implications:

    • Increased awareness of histoplasmosis panniculitis is crucial for early diagnosis and treatment.
    • Immunocompromised populations, including organ transplant recipients and those with acquired immune deficiency syndrome (AIDS), are at higher risk.
    • This case underscores the importance of considering fungal infections in patients with hematologic disorders and immunosuppression.