Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Childhood coronary sclerosis.

I Sakurai, A Tosaka, T Yamada

    Acta Pathologica Japonica
    |January 1, 1978
    PubMed
    Summary

    Childhood coronary sclerosis begins early, with intimal thickening and acid mucopolysaccharide accumulation in newborns. Fatty streaks and microthrombi appear later, indicating early arterial disease development.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Prolonged progression-free survival on epidermal growth factor receptor-tyrosine kinase inhibitors predicts superior response to atezolizumab-based therapy over chemotherapy in epidermal growth factor receptor-mutated non-small-cell lung cancer following progression.

    ESMO real world data and digital oncology·2026
    Same author

    Antioxidant activity of 3-methyl-1-phenyl-2-pyrazolin-5-one.

    Redox report : communications in free radical research·2016
    Same author

    Tetramethylbenzidine method for monitoring the free available chlorine and microbicidal activity of chlorite-based sanitizers under organic-matter-rich environments.

    Letters in applied microbiology·2015
    Same author

    Bronchiolitis and bacteraemia caused by Burkholderia gladioli in a non-lung transplantation patient.

    New microbes and new infections·2015
    Same author

    Flow regime classification in air-magnetic fluid two-phase flow.

    Journal of physics. Condensed matter : an Institute of Physics journal·2011
    Same author

    Cisplatin-based chemotherapy for advanced or recurrent endometrial cancer - a review of 36 cases.

    International journal of oncology·2011

    Area of Science:

    • Cardiovascular Pathology
    • Pediatric Cardiology
    • Arterial Biology

    Background:

    • Coronary artery disease (CAD) typically manifests in adulthood, but its origins may lie in childhood.
    • Understanding early atherosclerotic changes in pediatric populations is crucial for long-term cardiovascular health.
    • Histological and biochemical markers of early atherosclerosis in children are not fully elucidated.

    Purpose of the Study:

    • To investigate the histological, histochemical, immunohistochemical, and biochemical characteristics of childhood coronary sclerosis.
    • To identify the initial pathological features and potential contributing factors of early coronary artery disease in individuals aged 0-20 years.

    Main Methods:

    • Analysis of 60 autopsy cases from newborns to 20-year-olds.
    • Histological examination for intimal thickening, fibrocellular proliferation, and microthrombi.
    • Histochemical staining for acid mucopolysaccharide accumulation.
    • Immunohistochemical and biochemical analyses for beta-lipoprotein and fibrinogen infiltration.
    • Assessment of mural vascularization.

    Main Results:

    • Intimal thickening, characterized by fibrocellular proliferation and acid mucopolysaccharide accumulation, was observed in newborns, particularly at arterial branching points.
    • Microthrombi were present in infants, and fatty streaks generally appeared in the second decade of life.
    • Beta-lipoprotein and fibrinogen infiltration into the intima and mural vascularization were occasionally noted.
    • Arterial pressure effects and specific anatomical locations appear to facilitate plasma constituent entry into the intima, initiating sclerosis.

    Conclusions:

    • Childhood coronary sclerosis is initiated by intimal thickening and associated changes, even in infancy.
    • Plasma constituents and local circulatory disturbances within arterial walls may contribute to the progression of atheromas.
    • Early identification and intervention strategies for cardiovascular disease risk factors in children are warranted.

    Related Experiment Videos