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Real-World Data on: Attention Deficit Hyperactivity Disorder Medication Side Effects.

Elisa Cascade¹, Amir H Kalali, Sharon B Wigal

¹Ms. Cascade is Vice President, Quintiles Inc./iGuard, Falls Church, Virginia.

Psychiatry (Edgmont (Pa. : Township))

|May 29, 2010

Summary

Nearly half of patients taking medications for attention deficit hyperactivity disorder (ADHD) reported side effects, most commonly loss of appetite and sleep issues. However, few patients discussed these side effects with their doctors.

Keywords:

ADHD Attention deficit hyperactivity disorder amphetamine atomoxetine dexmethylphenidate dextroamphetamine isdexamfetamine methylphenidate patient-reported side effect side effect

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Using Brain Activation (nir-HEG/Q-EEG) and Execution Measures (CPTs) in a ADHD Assessment Protocol

Using Brain Activation (nir-HEG/Q-EEG) and Execution Measures (CPTs) in a ADHD Assessment Protocol

Published on: April 1, 2018

Area of Science:

Pharmacology
Psychiatry
Patient-Reported Outcomes

Background:

Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder.
Pharmacological treatments are a cornerstone of ADHD management.
Understanding patient-reported side effects is crucial for treatment adherence and efficacy.

Purpose of the Study:

To document and analyze patient-reported side effects from common ADHD medications in a real-world setting.
To identify the most frequent side effects associated with specific ADHD drug classes.
To assess the severity of reported side effects and patient communication with healthcare providers.

Main Methods:

A cross-sectional survey of approximately 325 patients using ADHD medications.
Tabulation of reported side effects for amphetamine and dextroamphetamine, atomoxetine, dexmethylphenidate, lisdexamfetamine, and methylphenidate.
Analysis of side effect frequency, bothersomeness, and disclosure to physicians.

Main Results:

48% of surveyed patients reported experiencing at least one side effect from their ADHD medication.
The most common side effects included loss of appetite, sleep disturbances, and mood changes.
Only 21% of side effects were rated as very or extremely bothersome, and just 20% of patients discussed any side effects with their doctors.

Conclusions:

Side effects are frequently reported by patients on ADHD medications, impacting treatment experience.
Commonly reported side effects like appetite and sleep issues require monitoring.
There appears to be a significant underreporting of side effects to prescribing physicians, highlighting a potential gap in patient-physician communication.