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Updated: Jun 12, 2026
Platform for Quantitative Detection of Endometrial Immune Cells Based on Immunohistochemistry and Digital Image Analysis
Published on: October 13, 2023
[Hormone receptors and markers in endometrial hyperplasia. Immunohistochemical study]
Alexandra Pungal1, Raluca Balan, C Cotuţiu
1Universitatea de Medicină şi Farmacie Gr. T. Popa Iaşi, Facultatea de Medicină, Spitalul Clinic Obstetrică Ginecologie Cuza Vodă Iaşi Clinica I Obstetrică Ginecologie.
Unlabelled:
Endometrial hyperplasia is a proliferation of the endometrium with increased number of glands and the change of the gland-stroma ratio. By histopathologic examination is now accepted the WHO classification. Atypical hyperplasia is accepted to be a precursor for endometrioid carcinoma. In order to find some prognostic elements, immunohistochemical reactivity of hormone receptors and markers in endometrial hyperplasia, was performed.
Material And Methods:
From 162 cases of EH, 32 cases were selected for immunohistochemical investigations. Avidin-biotin-peroxidase method was used for revealing estrogen and progesterone receptors (ER, PGR) and Ki-67 and EGF factors.
Results:
The immune reactivity for ER and PGR increase in parallel with the complexity of glandular morphological changes. Ki-67 demonstrated a strong immune reactivity together with EGF in atypical hyperplasias.
Conclusions:
The diagnosis of EH can be made by histopathological examinations. The immunohistochemistry aids for the prognosis, in order to establish the best treatment.
