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The Use of Gas Chromatography to Analyze Compositional Changes of Fatty Acids in Rat Liver Tissue during Pregnancy
11:08

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Study of lipid profile, lipid peroxidation and vitamin E in pregnancy induced hypertension

Suchanda Sahu1, Rebecca Abraham, R Vedavalli

  • 1Department of Biochemistry, Pondicherry Institute of Medical Sciences, Kalapet, Pondicherry - 605 014. suchandasahu@rediffmail.com

Indian Journal of Physiology and Pharmacology
|June 1, 2010
PubMed

Pregnancy-induced hypertension (PIH) is a common medical complication of pregnancy with a high incidence. The study comprised of 30 normal and 30 PIH cases in their third trimester of pregnancy and the following estimations were done: Serum Malondialdehyde level (MDA), Vitamin E, triglycerides (TG), total cholesterol (TC), HDL-cholesterol (HDL-C) and LDL-C. The PIH cases had significant rise in both systolic and diastolic blood pressure (BP) (P=<0.0001). There was a significant rise in the fasting triglycerides, total cholesterol and LDL-C levels in PIH (P=<0.0001). MDA was twice in the cases and Vitamin E was half the levels that of controls (P=<0.0001). The level of rise of serum lipids did not significantly correlate with the rise or fall in MDA. In PIH cases there was a negative correlation of diastolic BP with MDA (P<0.05). Early detection of these parameters is going to aid in better management of PIH cases.

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